Tricyclic Antidepressants

The Tricyclic (" three circles"...for the chemical structure of the molecule) antidepressants were once the mainstay of treatment in ADHD, but are used less frequently now. They have many side effects, especially dry mouth, dizziness when standing up quickly, blurring of vision, and constipation. They can be quite dangerous in overdose, especially compared to the newer SSRI's.

Several cases of sudden death in children have been reported on the tricyclic antidepressant Desipramine. This should be taken seriously, but these medicines have been used for decades in children with good responses in many cases.

An electrocardiogram is recommended prior to starting a tricyclic, and periodically while the medication is being given, or if the dose is raised significantly. There is not good evidence that this has any protective effect with regard to cardiac complications.

Examples

Name          Dosages

Imipramine  10,25,50 mg

Desipramine 10,25,50,75,100,150 mg

Nortriptyline 10,25,50,75 mg Capsules